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AZ7550 trimesylate salt
CAS No. 2319837-99-3
AZ7550 trimesylate salt( —— )
Catalog No. M33203 CAS No. 2319837-99-3
AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of non-small cell lung cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 226 | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAZ7550 trimesylate salt
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NoteResearch use only, not for human use.
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Brief DescriptionAZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of non-small cell lung cancer.
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DescriptionAZ7550 Mesylate is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
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In VitroAZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC50s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI50s of 19, 15, and 537 nM, respectively.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetIGF-1R
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RecptorIGF-1R
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Research Area——
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Indication——
Chemical Information
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CAS Number2319837-99-3
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Formula Weight773.9
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Molecular FormulaC30H43N7O11S3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (32.30 mM; Ultrasonic )
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SMILESO=C(NC1=CC(NC2=NC(C3=CN(C)C4=C3C=CC=C4)=CC=N2)=C(C=C1N(CCNC)C)OC)C=C.O=S(O)(C)=O.O=S(O)(C)=O.O=S(O)(C)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.?
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